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Vitamin B12 is a cofactor in synthesizing methionine, which is essential for protein formation.[ref] If you are deficient in B12 or folate for a long time, you can develop megaloblastic anemia

[9] Olexikov L, Dujkov L, Makarevich AV, Bezdek J, Sekaninov J, Nesvadbov A, et al

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