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While popular as a "study drug," the physiological toll can be significant

In individuals with pre-existing kidney impairment, which is not uncommon in long-standing diabetes, the drug's pharmacokinetics (how the body processes it) can be altered

Supply Challenges The surging popularity of Ozempic has led to supply issues

In hepatocellular carcinoma models induced by DEN combined with either high-fat/high-carbohydrate or low-fat/low-carbohydrate diets, lean m/db mice, and MCD- or CDE-induced liver injuryas well as in human models, exenatide activation of the GLP-1RcAMPPKAEGFRSTAT3 pathway suppressed oncogenic signaling, limited tumor cell growth, and enhanced apoptosis, resulting in a marked reduction in tumor progression (Zhou et al., 2017)