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We also included mechanistic evidence from young healthy adults and animal studies to help support and interpret findings from human studies when available and appropriate

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A 2014 mouse study found that NAC and vitamin E accelerated lung tumor progression and reduced survival.41 A 2015 melanoma mouse study found that NAC increased lymph node metastases in mice with malignant melanoma.42 A 2019 mouse study reported that NAC protected against emphysema-related lung damage but also induced lung adenocarcinoma in some mice.43 And a 2021 hepatocellular carcinoma study found that antioxidant supplements including NAC promoted tumor formation, growth, and drug resistance in experimental models by reducing intracellular ROS.3 Newer human data add another layer of complexity

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Research has shown that supplementation with CoQ10 can improve the in vitro maturation rate of immature oocytes in patients with endometriosis compared to those who do not receive the supplement (Romero et al., 2020)

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