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When combined with GLP-1 medications, a nutritious diet can help enhance the medication's appetite-regulating effects and promote a more balanced, sustainable approach to weight loss

Electrophysiological recordings support this notion and have demonstrated that GLP-1 directly stimulates POMC/CART cells, whereas GLP-1 can also inhibit orexigenic NPY/AgRP cells in the ARC through an indirect mechanism (Secher et al., 2014)

semaglutide has balanced signaling Weight loss : Comparable Phase 3 results (~15%), but different populations and durations Evidence base : Semaglutide has 25,000+ patients and 7+ years

doi:10.1016/j.peptides.2017.08.003