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Common side effects include gastrointestinal symptoms, with berberine potentially interacting with diabetes medications and drugs metabolised by CYP enzymes

(PubMed) Luo T, Li J, Li L, et al

Experimental design In order to generate the murine models of PCOS, C57BL6/J male and female mice were purchased from Charles River Laboratories (France)

J Physiol (2014) 592(10):218396.10.1113/jphysiol.2013.268771 143 IgawaHTakahashiMKakegawaKKinaAIkomaMAidaJet alMelanin-concentrating hormone receptor 1 antagonists lacking an aliphatic amine: synthesis and structure-activity relationships of novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one derivatives