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For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24
Outcomes To investigate the long-term clinical and economic outcomes of various anti-diabetic treatments, researchers utilized the CORE diabetes (Center for Outcomes and Resource Evaluation) model, which simulates morbidity, mortality, and associated healthcare costs based on epidemiological data from extended clinical trials (16)(17)
doi:10.1016/S0140-6736(13)62062-0 99
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