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There are no known direct drug interactions between semaglutide and testosterone

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[1] [2] Based on pharmacological principles, it typically takes five half-lives for a medication to be considered essentially eliminated from the body (approximately 97% cleared)

After a 2 week screening period all eligible participants were randomly assigned to treatment groups receiving either a subcutaneous injection of 2.4 mg of semaglutide, 2.4 mg of cagrilintide, a combination of cagrilintide and semaglutide, a semaglutide placebo, or a cagrilintide placebo [2]