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Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. The semaglutide extension follows the same direction. The pattern reflects removal of appetite suppression after major weight loss

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The drug causes a reddish discoloration of the urine (chromaturia, which can look like blood in the urine), and of the skin