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335 One large observational study examined data from 83,010 male veterans with low testosterone levels and found risks of heart attack, stroke, and all-cause mortality were significantly reduced in those who reached normal testosterone levels with TRT compared with those who did not achieve normal testosterone levels with TRT and those who did not receive TRT

Converting mg/mL to mcg/mL: Multiply by 1,000 (e.g., 1 mg/mL = 1,000 mcg/mL)

ATF4 directly binds to the ATF/CRE element to activate transcription

Men with PD or AD were documented, in a meta-analysis, to have higher levels of Hcy than women (Nguyen et al., 2023)