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In vivo testing of nanotherapeutics for osteosarcoma treatment: Translational challenges and solutions
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demonstrated that native GLP-1 10nM downregulated adipogenic markers ( PPAR , adipose differentiation-related protein ( ADRP ), FABP4 ) and lipogenic genes ( LPL , fatty acid synthase ( FASN ), sterol regulatory element-binding protein 1 ( SREBP1 ), while increasing lipolytic markers hormone-sensitive lipase ( HSL ), Perilipin and adipose triglyceride lipase ( ATGL ) in Stromal Vascular Fraction cells (SVFCs) of adipose tissue during adipogenic differentiation [31]
Conversely, in another study with 10 healthy adults where glucose levels were maintained between 70 80 mg/dL, fat ingestion elicited a fivefold to sixfold rise in GIP levels without concomitant insulin secretion (119)
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