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doi:10.1016/j.nbd.2012.09.015 3

Adding ketamine infusions can help reduce the reliance on high doses of these medications by directly addressing pain and mood symptoms, potentially mitigating adverse effects associated with long-term medication use

Health 49 , 597604 (2011)

The flushing response characteristic of niacin can be accompanied by transient reductions in blood pressure, which could pose risks for patients with compromised cardiovascular function