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Emerging evidence suggests that GIPR antagonism could improve the tolerability of agonists by reducing nausea, according to a 2025 study 9

18+ years old Type 1 diabetes and used insulin for at least one year A1c of 7.5% to 10% Administering insulin via multiple daily injections (MDI) or insulin pump user with total daily insulin between 0.3 and 1.5 units per kilogram Body Mass Index (BMI) greater than 18.5 (Calculate your BMI here) Exclusion criteria include: A history of type 2 diabetes Past treatment for type 1 diabetes with any other glucose-lowering drug except basal and bolus insulin during the last three months Severe hypoglycemia or diabetic ketoacidosis in the past three months For a full list of inclusion and exclusion criteria see here

Currently, however, there is no broader research in this area

The data were analyzed using the 2-Cq method (18)