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Nevertheless, to assess the robustness of our findings, we performed sensitivity analyses adjusting for GA alone (Model B) and for GA in addition to the DAG-selected confounders (Model C)

A causative role for periarticular skeletal muscle weakness in the progression of joint damage and pain in OA

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2.1.3.4 Altered macrophage polarization (M1/M2 balance) Macrophages are plastic and can shift phenotypes depending on cues classically activated M1 are pro-inflammatory and microbicidal, whereas alternatively activated M2 are anti-inflammatory and involved in repair ( Figure 2 )