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Treatment of malaria with these drugs can cause (severe) hemolysis in G6PD-deficient individuals (i.e., males having a variant G6PD or heterozygous females with skewed The Importance of Reduced Glutathione in Detoxification Click The Image Reduced Glutathione NADPH produced in the oxidative phase of the pentose phosphate shunt maintains the cysteinyl sulfur of glutathione in the reduced state

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