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30970633 and 31270851), Doctoral Funding Grants, Norman Bethune Health Science Center of Jilin University (No.470110000006) and Graduate Innovation Fund of Jilin University (No.2014060)

however, in a number of patients, there may be spontaneous recovery, ultimately leading to complete relief from symptoms [3, 19]

Long-term use of acid-suppressing medications carries significant risks, including nutritional deficiencies (particularly vitamin B12, magnesium, iron, and zinc), an increased risk of Helicobacter pylori infection, small intestinal bacterial overgrowth (SIBO), and stomach ulcers

Importantly, the differences in Ex4 and P5 in vivo efficacy are not due to differences in peptide pharmacokinetics as both peptides display similar half-life in mouse serum (supplementary Fig