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Together, these findings demonstrate that, in contrast with acute exposure, chronic disruption of iron homeostasis with consequent GSH depletion remodels cellular redox homeostasis over time, inducing a state we term chronoferroptosis: a persistent ferroptotic adaptation characterized by coordinated alterations in iron-handling and antioxidant defense proteins that may represent early vulnerability to neurodegenerative pathology
[Mechanism Applicable to Mammalian Systems] Forman HJ, Zhang H, Rinna A
It is particularly useful for studying transient or weak interactions between proteins
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