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At the starting 0.25 mg/week dose, effects are usually mild

Free radicals damage skin cells, accelerate collagen breakdown, and trigger the melanin production that leads to dark spots, uneven tone, and premature aging

This finding is particularly relevant because fatty liver disease affects a substantial percentage of people with obesity and can progress to serious conditions like cirrhosis and liver cancer

When combined, these complementary mechanisms can produce GH release exceeding the sum of individual effectsa phenomenon documented across multiple preclinical models