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[1] Adverse effects [edit] Safety and dosing trials showed that the incidence of adverse events in orforglipron-treated participants was 6289%, mostly from gastrointestinal discomfort (4470% with orforglipron, 18% with placebo)
Combined 5-MTHF + methylcobalamin support is the standard nutritional intervention for MTHFR T/T-associated functional folate insufficiency
Side effects and safety profile Understanding risks and contraindications
It also noted that as B12 deficiency increased, so too did insulin resistance
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