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MCART1/SLC25A51 is required for mitochondrial NAD transport
Titration from 0.25mg to 0.5mg over 710 days allows receptor density to adjust, minimizing adverse events while building toward maintenance dosing of 0.51mg twice weekly
Place stronger human or clinical-context evidence toward the top and preclinical or regulatory-safety context below
2 expression is highly upregulated by exogenous GSH supplementation indicating a substrate-dependent regulatory mechanism ( Given the growing body of literature on CHAC proteins, a comprehensive overview of all published work is beyond the scope of this review
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