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Two 2013 systematic reviews of interventions concluded that the modest benefit of propionyl-L-carnitine on walking performance was equivalent or superior to that obtained with drugs approved for claudication in the US (e.g., pentoxyphylline, cilostazol) yet inferior to improvements seen with supervised exercise interventions (69, 70)

It is particularly effective for patients who have experienced facial volume loss or mild skin sagging due to weight loss

However, the question of whether the benefits observed in rats might also apply to humans will not be easy to determine

Additionally, the addition of carrier proteins (such as 0.1% HSA or BSA) can aid in long-term storage stability