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The two products follow different regulatory frameworks, different stability testing protocols, and different shelf-life designations

With respect to hematological parameters, Bonferroni-adjusted pairwise comparisons showed that red blood cell (RBC) count, hemoglobin (Hb), and hematocrit (Ht) levels were significantly higher in the 14 mg group than in the 3 mg group (p = 0.014, p = 0.027, and p = 0.017, respectively), as shown in Supplementary Figure 2

established a direct neurotoxic action by acetaminophen both in vitro and in vivo in rats at doses below those required to produce hepatotoxicity and suggested that this neurotoxicity might be involved in the general toxic syndrome observed during patient acetaminophen overdose and, possibly, when acetaminophen doses in the upper dosing schedule are used, especially if other risk factors (moderate alcohol drinking, fasting, nutritional impairment) are present