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Desde su salida al mercado, los Endocrinos nos sentimos muy cmodos con la prescripcin de este frmaco, ya que su principio activo es Liraglutide, el mismo que est presente en otro frmaco, Victoza , que se vena usando en Espaa para diabetes tipo 2 desde el ao 2011: haba demostrado un excelente perfil de eficacia y seguridad, as como un efecto marcado en la bajada de peso
Tirzepatide (Mounjaro, Zepbound) Strengths: Highest efficacy for both glucose control and weight loss Dual mechanism (GLP-1 + GIP) may provide unique benefits Once-weekly dosing Generally well-tolerated Considerations: Higher cost than semaglutide Less long-term safety data (newer medication) Cardiovascular outcome trial not yet complete (though expected to be positive) Best for: Patients prioritizing maximum weight loss
Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion
Ophthalmol Sci
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