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The Diabetes Prevention Programme, a large RCT comparing Metformin, ILI and placebo, indicated that after 21 years of follow-up, there was no significant reduction in cancer incidence comparing ILI to placebo (RR 0.96, 95% CI = 0.791.18) [14]
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Tirzepatide may also be considered for adults struggling with obesity or overweight, especially if you have related health concerns such as high blood pressure, high cholesterol, or heart disease, and have not seen results from diet and exercise alone
Exenatide and dulaglutide showed no significant impact on mental health outcomes
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