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Drugging this type of GPCR with small molecules has its challenges say Jeff Finer, chief executive of Septerna, a biotech based in south San Francisco, US
In the dosing conditions trial, subjects were randomised into eight treatment groups, in which 10 mg oral semaglutide was administered once-daily for 10 days with either 50 or 120 mL water, and the duration of post-dose fasting was either 15, 30, 60 or 120 min
The guidance notes that there is limited data on GLP-1s long-term safety, efficacy and affordability, among other unknowns
Granhall C, Donsmark M, Blicher TM, Golor G, Sndergaard FL, Thomsen M, Bkdal TA
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