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Variants of OXM resistant to DPP-IV (achieved by addition of PEG [86], fatty acids [87], substitution of certain amino acids [85] or even combined modifications [88]) have been advanced to circumvent the limited clinical potential of the native peptide
Wu S, Zhu J, Wu G, Hu Z, Ying P, Bao Z, et al
Who Should Exercise Caution With This Treatment Patients with pre-existing hypotension, established cardiovascular disease, chronic kidney disease, poorly controlled hypertension, or a history of pancreatitis or medullary thyroid carcinoma would require specialist oversight and careful riskbenefit assessment before any future use
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