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Semaglutide 1 mg weekly reduced the composite primary kidney outcome (defined as a 50% or greater eGFR decline, end-stage kidney disease, or kidney or cardiovascular death) by 24% (HR 0.76)

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However, the medication's gastrointestinal effects like diarrhea and constipation may indirectly contribute to conditions such as hemorrhoids or anal fissures that cause rectal bleeding

Eysiaks W, Lilly K, Dilisao F, Toth PP, Bieber LL (1988) The journal of biological chemistry quantitation of the effect of L-Carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria*