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Together these observations are consistent with an important concept: microglia are the earliest responders to a primary multifocal myelin injury in the MS white matter, and importantly, this injury/response seems to precede lymphocytic infiltration, arguing against adaptive immune cells being the primary drivers of white matter injury
DOI: 10.1021/ja010512t 52
The combination effect ( = 7.63) is statistically significant and has been confirmed by every subsequent meta-analysis
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