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[2] [3] Simultaneously, it suppresses glucagon secretion from alpha cells, reducing hepatic glucose production
Ozempic is also prescribed to reduce cardiovascular adverse events (heart attack, stroke) and worsening kidney disease in certain people with diabetes and other conditions
In people with obesity and established cardiovascular disease but without diabetes, semaglutide 2.4 mg resulted in 20% reduction in major adverse cardiovascular events [(MACE), death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke] compared to placebo (SELECT trial) after a mean follow-up of 39.8 months this is the first trial demonstrating cardiovascular benefit for an obesity pharmacotherapy [110]
Optimal metabolic function requires both sufficient hormone production and robust receptor-mediated signaling
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