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Converging evidence suggests that reductions in cerebral blood flow (CBF) and cerebrovascular dysfunction may precede structural and functional deficits associated with neurodegeneration, representing one of the earliest indicators of ADRD risk (Jack et al., 2010), and therefore, cerebrovascular dysfunction may serve as an ideal early-stage biomarker that is receptive to aerobic exercise interventions (Kleinloog et al., 2019

Both medications can produce meaningful weight loss when combined with the nutrition and lifestyle changes they make easier to sustain

Sometimes we'll go down if they're having side effects

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