glp-1 controversy A Closer Look at the Dermatological Profile of Agonists Out of Shortage, Into Controversy:

Possible role of lysolecithins and nonesterified fatty acids in the pathogenesis of Reyes syndrome, sudden infant death syndrome, acute pancreatitis, and diabetic ketoacidosis

Orforglipron significantly reduced HbA1c to 2.1% in a phase II clinical trial assessing its use in T2DM, while dulaglutide achieved 1.1% and a placebo achieved 0.43% [106]

suggested that injection of NBP inhibited erastin-induced accumulation of iron and ROS, downregulated TFH, and upregulated Nrf2, which in turn inhibited ferroptosis and reversed the damage to DAergic neurons (MES23.5 cells) (Ye et al., 2023)

They bind to receptors on cells and trigger a range of biological effects, from the regeneration of tissue to the production of hormones making them an increasingly important class of drugs