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Use of incretin-based therapies in women using hormone replacement therapy (HRT)

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An embodiment of present invention provides a process for purification of compound of forumula-13, comprising subjecting a solution of compound of formula- 13 to RP-HPLC purification by using buffer solution as mobile phase- A and acetonitrile as mobile phase-B

Semaglutide is associated with a modest increase in gallbladder disease risk beyond that attributable to weight loss alone, with cholelithiasis reported in 1.62.5% vs 0.71.0% and cholecystitis in 0.6% vs 0.2% of Wegovy vs placebotreated adults in weightmanagement trials, and higher rates in adolescents