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There are two types of melanin in the skin: eumelanin and pheomelanin

173 Animal studies show that SIRT1 activation reduces MDA content, ROS accumulation, and mitochondrial membrane potential loss, ultimately delaying hepatocyte apoptosis

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Elevated CHAC1 is associated with the induction of ferroptosis, highlighting the role of STAT3 as a modulator of CHAC1 and ferroptosis in colorectal cancer cells (Zhao and Chen, 2021)