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Method Umbrella review methods This umbrella review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and is prospectively registered with PROSPERO (CRD42024585231)
Even small amounts of degradation products or synthesis impurities can introduce unintended receptor interactions or background signaling activity that complicates interpretation in receptor binding assays, metabolic pathway studies, and cell-based experiments
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