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Increased expression of the FMO3 gene could be a culprit in atherosclerosis and CVD.8 FMO3 may have adverse effects on blood lipids and glucose independently of TMAO formation, although more research is needed.15 Also, in the liver, trimethyllysine (TML), a modified amino acid, can be converted to GBB and then to carnitine and potentially to TMA and TMAO
Keep in mind that natural products arent always suitable for everyone, and getting the dosage right is crucial
However, with appropriate dose adjustment and consistent use, oral formulations can support meaningful clinical response for many patients
Third, clinicians should review contraindications carefully
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