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Start: 200 mcg once daily Increase: Add ~200 mcg every 2 weeks as tolerated Target Range: 400600 mcg once daily Frequency: Once daily Cycle Length: Typically 812 weeks Timing: Any consistent daily time

For the separate analysis of results from the investigator-initiated study and the Phase I trial, the database was locked and loaded into SAS version 9.4 (Statistical Analysis Software

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Real, visible density changes that show up in photographs or that other people notice typically take 3 to 6 months