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v3 integrins mediate flow-induced NF-B activation, proinflammatory gene expression, and early atherogenic inflammation

It also promotes muscle protein synthesis, improving both hypertrophy and recovery between sessions

It is handed between proteins in a thermodynamic hierarchy, and the relevant partners named in the GHK literature include serum albumin, which has a dedicated high-affinity N-terminal site, ceruloplasmin as the dominant circulating copper protein, metallothioneins as high-capacity intracellular sinks, and cuproenzymes that require the metal to function