semaglutide leptin restores astrocyte–vascular interactions and blood–brain barrier integrity in a model of diet-induced metabolic syndrome | Diabetology & Metabolic Syndrome The leptin-melanocortin pathway and its

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Semaglutide medications work by mimicking increased levels of a hormone called GLP-1 (glucagon-like peptide 1), a satiety signal that slows digestion and makes us feel full

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What to Expect: GLP-1 Side Effect Reality Check Nausea : The most frequently reported side effect, typically more prominent when first starting or increasing doses Vomiting : Less common than nausea, possible during initial adjustment Diarrhea or constipation : Can occur alongside other GI effects Reduced appetite : A therapeutic effect that helps with weight loss, but can sometimes feel uncomfortable Many patients report that side effects decrease significantly after the first few weeks, and severe reactions requiring discontinuation are relatively rare