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Pivotal trials: what the NEJM data show Semaglutide STEP-1 (2021) and SELECT (2023) STEP-1 (Wilding et al., NEJM 2021) randomized 1,961 adults over 68 weeks on semaglutide 2.4 mg/week
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Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice
The combination of exercise-induced heart rate elevation plus stimulant effects may feel uncomfortable and potentially stress the cardiovascular system unnecessarily
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