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A 2024 Phase 2 trial in Nature Medicine (Sanyal et al.) showed liver fat fell by 43% to 82% across the dose range in 24 weeks in patients with MASLD
The peptide functions as a precision senolytic agent by competing with endogenous FOXO4 for p53 binding, releasing the tumor suppressor protein to trigger apoptosis specifically in cells that have accumulated the senescence-associated secretory phenotype (SASP) markers
The American Academy of Ophthalmology highlighted this study, saying it showed patients taking semaglutide the active ingredient in Ozempic and Wegovy may be at higher risk of developing an eye condition that can cause blindness. For NAION, however, rare though it is, I do believe sight-related side effects should be given a more prominent place on the label
However, if you are one of the millions of people in the UK living with a thyroid condition, the excitement is often tempered by a significant question: Is it safe
