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J Biochem Mol Toxicol 32:e22016
PubMed laboratory research record [PMID: 39580054] PubMed record related to this compound for laboratory literature review
Ardehjani NA, Agha-Hosseini M, Nashtaei MS, et al
OXTR binding activates downstream G protein signaling cascades, primarily Gq/11, leading to: Increased intracellular calcium mobilization and activation of downstream kinases Modulation of amygdala responsiveness to socially relevant stimuli Altered activity in reward-related circuits including the nucleus accumbens Reduced cortisol and HPA axis activation in stress paradigms fMRI studies have consistently demonstrated reduced amygdala activation in response to threatening social stimuli following intranasal oxytocin administration, a finding replicated across multiple research groups[2]
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