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Once-Weekly Retatrutide Reduces Weight and Knee Pain in Patients With Obesity and Osteoarthritis Kennedy Ferruggia, Associate Editor Ron Panarotti Key Takeaways Retatrutide, a triple hormone receptor agonist, achieved significant weight loss and pain improvement in individuals with obesity and knee osteoarthritis over 68 weeks

All results given concern published clinical trials of the cagrilintide + semaglutide combination and should not be interpreted as a promise of effect, an instruction for use or a claim about the effect of the research-grade product offered by Peptology

Ability To Introduce Combination Therapy Incrementally Clinicians may phase medications instead of initiating full combination exposure immediately

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