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Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin
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More recent publications have examined the long-term stability profile of reconstituted growth-hormone-releasing peptides (GHRPs), incretin mimetics like tirzepatide and retatrutide, and tissue-repair peptides like BPC-157 when paired with preserved diluents as the choice
Kopp KO, Glotfelty EJ, Li Y, Greig NH (2022) Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: implications for neurodegenerative disease treatment
