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In terms of inflammation, MC4R KO mice showed pro-inflammatory gene expression, such as TNF-alpha and IL1-beta in liver and white adipose tissue (WAT), indicating inflammation are activated in liver and WAT (Fig
Arch Toxicol 97:24992574
D.FodorJ.PognyM.PreussJ.BarnaB
Intestinal microorganisms have the capacity to biotransform flavonoids into active metabolites that are more readily absorbed or, alternatively, into less bioactive forms ( Microbial Biotransformation of Flavonoids: Specific gut microbes hydrolyze flavonoid glycosides, yielding absorbable aglycone forms
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