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Effect of conjugation on directing metabolite excretion.Phase II conjugation often creates anionic metabolites that are then efficiently excreted into the bilevia transporters
A Phase-3 randomized clinical trial showed that the efficacy of HSK16149 capsules was superior to placebo in all groups for relieving PDPN and appeared well tolerated
Gastrointestinal symptoms typically peak during the early titration weeks and subside for many as the body adapts
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