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The FDA and the EMA have stated that after review of published and unpublished reports, the current data do not support an increased risk of pancreatitis and pancreatic cancer in patients receiving incretin mimetics

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Adding Norethisterone on top of the combined pill is not appropriate, both contain progestogens, and stacking them increases the risk of side effects such as breakthrough bleeding, mood changes, and a small but real raised risk of venous thromboembolism (VTE)

Electrospray ionization in positive mode and multiple reaction monitoring are applied for detection