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As our results showed, there is no difference between them in terms of efficacy, but in terms of patients tolerance, advantages, and disadvantages of each route, the sublingual route is preferred over IM and oral routes
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Indeed, nodose GLP-1R lentivirus-mediated knockdown increases postprandial glycemia 128 , and Glp1r Phox2b/ mice, which exhibit selective knockout of GLP-1R in the nodose ganglia, midbrain, and hindbrain, exhibit increased fasting levels of glucose, both highlighting a role for GLP-1 vagal afferent signaling in mediating glucose homeostasis 127
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