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The standard progression, starting at 2.5 mg and increasing by 2.5 mg increments every 4 weeks, emerged from extensive clinical trials designed specifically to balance efficacy against tolerability
For example, the cytokine tumor necrosis factor-alpha (TNF-), produced during inflammation, can activate NF-B and other pro-survival pathways in cancer cells [112]
Indeed, examination of the model suggested that the side chain of X u 1 did not project in the same direction as in X1
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