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The FDA approval pathway exists to verify that a medication's benefits outweigh its risks across thousands of patients over longer periods than phase 2 captures
The most commonly reported Retatrutide side effects in clinical research have been gastrointestinal, especially nausea, diarrhea, vomiting, and constipation
The SURMOUNT-5 study also found that tirzepatide was associated with slightly fewer treatment discontinuations due to gastrointestinal side effects
According to Vashisht of Healthify, the company built its thesis on GLP-1-assisted weight loss in 2024 in the US market, where it was operational
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