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They also observed less response to GLP-1 in the pancreas and in the gut of these mice, indicative of GLP-1 resistance, yet there was no change in the expression of GLP-1 receptors in these tissues

[11] It results from a localized defect in the phrenoesophageal ligament while the gastroesophageal junction remains fixed to the preaortic fascia and the median arcuate ligament

Patients should be counselled about these potential risks and advised to report any severe or persistent symptoms to their healthcare provider promptly