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The PKA inhibitor 8-Br-Rp-cAMPS (Rp-cAMPS) was purchased from BioLog Life Science Institute (Bremen, Germany), the SSTR2 antagonist CYN154806 from Tocris Bioscience (Bristol, UK), the Gpr119 agonist AS1269574 from Tocris and pertussis toxin from Sigma

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Activating it helps promote insulin secretion, slows down gastric emptying (making you feel full longer), and signals satiety to the brain

Over the eight hybrids selected, five had improved stability in mouse plasma with the insertion of the triad at various positions on the peptide